This book introduces a research design framework for today's researchers who are experiencing growing crisis in contemporary research methodologies where traditional qualitative approaches struggle with scale and complexity, and computational methods risk epistemic reductionism. The framework consists of a methodological architecture that integrates philosophical foundations, research processes, human-AI collaboration, and validation into a unified approach for AI-assisted qualitative research. It provides guidance for conducting research from problem formulation through theory development and governance. Written for doctoral researchers, methodologically engaged scholars, and advanced practitioners in social, organisational, and policy research, the book speaks to those working with large-scale, complex, and digitally mediated qualitative data.