This book constitutes the proceedings of the CVPR 2025 Challenge on Foundation Models for 3D Biomedical Image Segmentation, MedSegFM 2025, held in Nashville, TN, USA, during June 11-15, 2025.

The 13 full papers included in this book were carefully reviewed and selected from 19 submissions. This conference provides state-of-the-art algorithms for biomedical image segmentation foundation models.