The book discusses post-COVID-19 conditions, a multisystem syndrome with persistent symptoms that affect quality of life, especially in vulnerable populations such as women, older adults, ethnic minorities and people with comorbidities. It highlights the diagnostic complexity due to the lack of biomarkers and symptomatic heterogeneity, aggravated by social, economic and structural barriers that limit access to adequate care. It proposes a comprehensive approach that combines prevention through vaccination, humanized clinical diagnosis and multidisciplinary management adapted to diverse contexts. It also emphasizes the need for inclusive public policies, community support systems and targeted research to reduce inequities and achieve equitable and sustained care.