The two-volume set CCIS 2617 and 2618 constitutes the refereed post-conference proceedings of the 5th International Conference on Optimization, Learning Algorithms and Applications, OL2A 2025, held in Sesti Levante, Italy, during April 28-30, 2025.

The 38 revised full papers presented in these proceedings were carefully reviewed and selected from 92 submissions. The papers are organized in the following topical sections:

Part I: Optimization; Optimization in Control Systems Design; Artificial Intelligence in Healthcare and Medicine; and Deep Learning.

Part II: Optimization in the SDG context; Machine Learning; and Machine Learning and Artificial Intelligence in Robotics.