This monograph approaches from various angles the problematic difficulties of definition of multiple sclerosis. Although no figures or tables are included, a schematic series of attempts are made in terms of short review style the overall and specific highlights of pathologic involvement of the central nervous system in neurodegeneration,neuroinflammation and demyelination as seen in autopsy material. A clear concise style has been adopted that allows however the establishment of comprehensive inclusion of various pathogenic features of operative schematization of current understanding in MS pathogenesis. This volume is particularly suitable in view of the organic structuring of various operative factors in MS that interest students, post-graduates researchers of various disciplines, and also integrative information of interest to clinicians in active clinical investigations, and also pathologists and neuropathologists.