The authors in this book analyze resilience and sustainability in seven different complex adaptive systems (human beings, megaprojects, higher education, food systems, climate change, healthcare settings and cities) by highlighting transitions from complexity to transdisciplinarity as a strategy for knowledge integration. The book provides insights about the nature of complex adaptive systems based on the cases studied, in particular the issue of second order cybernetics (associated to the mind-matter problematic), the role of entropy in complex systems and the importance of the notion of reflexivity in the current cognitive-reflexive stage in world capitalism. In this way, the book aims at contributing to current debates and objections about the validity of traditional ontological and epistemological positions in the face of radical and rapid transformations worldwide affecting some aspects of capitalist development. The Conclusions explore how complex sustainability needs to integrate several elements beyond the conventional view expressed in the standard, anthropocentric definition of sustainability. The contributions in this book are important for anyone interested in meaningfully designing research on resilience and sustainability that uses complexity and transdisciplinary perspectives and frameworks.