In the dynamic landscape of bioinformatics and blockchain technology, a profound challenge is evident: ensuring secure exchange and analysis of complex biological data while maintaining data integrity and ownership. Traditional methods fall short in seamlessly transferring genomic data, spurring the fusion of blockchain innovation and optimization algorithms as a groundbreaking solution. Biology-Inspired Optimization Techniques in Blockchain Systems directly addresses the data integrity and ownership dilemma in bioinformatics and blockchain. Despite the intricacies of genomic data, blockchain's potential solution faces obstacles like data volume and slow transactions. These challenges are adeptly overcome through optimization algorithms. The book, authored by experts in bioinformatics, blockchain, and optimization, offers a comprehensive guide, showcasing how blockchain architecture and biological data intricacies can harmonize. It provides a blueprint for using blockchain to store genomic variants and aligned reads. This work empowers developers, data scientists, and researchers to overcome technological barriers, redefining the landscape of bioinformatics and beyond.