Understand Disease Mechanisms, Apply Knowledge, and Think Like a Clinician.

About This Text

This concise, well-organized text links normal physiology to the pathophysiology of common disorders and shows how mechanisms guide diagnostics and management. Learn why patients present with specific symptoms, how to interpret results, and how to translate science into clinical decisions. Includes case studies, more than 500 images, and end-of-chapter key points.

What's New in the Second Edition

• Physiology of pregnancy, labor, and delivery
• Expanded neonatal and pediatric development section
• Cell-free DNA methylation (epigenetics) patterns in oncology
• Expanded fluid and electrolyte balance section
• Enhanced section on the social determinants of health
• Introduction of the exposome concept in human disease
• Updates on biological and psychosocial aspects of sexual development, including LGBTQ+-centered care

Why Students Love This Text

• Clear, concise content connects physiology to pathophysiology and real-life care
• Bridge to Clinical Practice sections help translate concepts to practical patient care.
• Over 500 full-color images illustrate and simplify complex ideas
• Case studies and critical-thinking questions build clinical decision-making skills
• Chapter summaries and key points reinforce learning
• Comprehensive lifespan coverage from pediatric to geriatric care