Heavy metals and metalloids are persistent environmental pollutants that can be deleterious in excessive amounts; these destabilize ecosystems by inducing bio-accumulation in organisms. Efficacy of different doses of arsenic in the brain tissue of L. cuprina(Wiedemann) was observed through histological slide preparations by feeding and injectiontreatments as well as control. Arsenic-induced mortality was also observed for both the treatments and control flies. 0.01 ppm, 0.05 ppm, 0.1 ppm, 0.5 ppm, and 1 ppm of As were administered in the treatments. The mortality was observed for 72 hours and the total mortality within this time was corrected by using Abbott's correction formula. The mean mortality due to various doses of As in both cases was analyzed using one-way ANOVA by SPSS (v. 26) and the posthoc analysis was conducted by Duncan's Multiple Range Test.