Background: Each year, schools all over the world suffer from disasters, ranging from small to large damaging disasters that affect children safety and health.Teachers play significant roles in child protection. Therefore, teachers' training is very important for effective school disaster management. Aim: This study aims at evaluating the effectiveness of educational instructions on school teachers' knowledge and skills regarding disasters and first aid management of school children. Subject and methods: Quasi-experimental design utilized for conducting the study. Purposive sample of 59 school teachers from Mostafa Kamel preparatory school and Emad Ali Kamel primary school, Cairo Egypt allocated. Data collected through; demographic data, school teachers' first aid and disaster management knowledge, observation checklist for first aid and disaster management. Results: the study revealed that, regarding knowledge, 18.6% of teachers had satisfactory first aid knowledge pre intervention; meanwhile post intervention was 66.1%. For practice, 59.3% of them gained adequate first aid practice after implementation of program, while pre intervention only 10.2% of them had.