Heat transfer fluids play very important roles in many industries including power stations, production processes, transportation and electronics. The so-called nanofluid becomes a hot debate among the researchers and it is leading to a new revolution in thermal and heat transfer performance as new working fluid in recent decade. The present work studied the typical water based Cu nanofluid and CNTs nanofluids thermal performance: The convective heat transfer coefficient of Cu nanofluid with different volume concentrations under different flow regimes has been investigated and given very positive suggestions for Cu nanofluid application as heat transfer working fluid; For CNTs nano fluid, the research focus on the enhancement of thermal conductivity by influence of CNTs dispersion. The methods and guidelines probably bring audience bright ideas about how to better use the merits of CNTs as high efficient heat transfer nanofluid.