Humanity faces three main challenges. To "save the planet", as pursued by the 17 goals of UN 2030 agenda: tackling climate change, etc... The second, space exploration, will maybe take us to Mars. The third challenge is to save civilization. This third challenge is disattended and neglected, but eight billion terrestrials cannot save their civilization if they will not begin immediately to expand into space. Expanding into space is different from just exploring space. Exploration can be done by trained astronauts, able to bear 4-5G acceleration and hard and dangerous re-enter in atmosphere, during short missions. To travel, work and live in space we have to safeguard our life and health: protection from cosmic radiation, artificial gravity, low accelleration, safe reenter, etc. A full change of paradigm. I¿d like to see not only the space tourism branch facing this problem. I¿d like to see many other industrial, commercial and governmental branches to tackle this challenge: saving civilization from a possible implosion, due to the many problems we have on this, now, small planet. (From a speech given by A. Autino at the UNISPACE+50 Conference, at UN in Vienna, the June 19th 2018).