"A sign is that which shows itself to meaning" (St. Augustine of Hippo, 354-430, d.c. The Dialectic, 397). Semiotics today, as a scientific discipline, proposes a reflection on its due reinsertion in educational practice. This discipline is characterized by its transdisciplinarity and its transcendence permeates the other disciplines of human knowledge, with social implications of production, circulation and interpretative reception of meanings in the construction of meaning, which generate new semiotics and new knowledge in every significant practice. This work is the result of my academic experience, compiled from the notes and working materials of the seminars on semiotics I took during my studies for the Doctorate in Human Sciences, which has been enriched with contributions from professors and by the research I have carried out, which has complemented the content of this book, with the aim of contributing to the academic debate on Semiotics and Education in the Human Sciences and its contribution to scientific knowledge.