Research Paper (postgraduate) from the year 2013 in the subject Chemistry - Organic Chemistry, , course: DOCTOR OF PHILOSOPHY IN CHEMISTRY, language: English, abstract: 1-chloro-4-(p-tolyolxy)benzene react with 1-(4-hydrogy phenyl)-ethanone in presence of copper metal as a catalyst gives 1-(4-(4(p-tolyolxy) phenoxy)phenyl )ethanone,this derivatives react with various substituted aldehyde to give corresponding substituted chalcone derivatives (N-1).Now these derivatives(N-1).on condensation with used gives 6-phenyl-4(4-(4-(p-tolyolxy) phenoxy) phenyl)-5,6-dinydropyridinmin-2(H)-one (N-2) Structure elucidation of synthesized. Compound has been made on the basis of element analysis, 1H NMR Spectra studies.The microbial activity of the synthesized compounds has been studied against the species bacillus subtillis, staphylococcus aureus, Escherichia coli, and salmonella typhi.